Validation of new biomarkers in systemic autoimmune diseases
نویسندگان
چکیده
منابع مشابه
Biomarkers in Systemic Autoimmune Diseases
In an ideal scenario, a biomarker would both reveal the driver of disease and identify an effective treatment. In oncology, genetic biomarkers that molecularly or clinically classify patient populations for targeted therapies, e.g., BRAF [1] and HER-2 [2], have been clinically validated and are reaching this ideal. However, biomarkers are necessarily based on the pathobiology of the underlying ...
متن کاملSystemic Autoimmune Diseases 2014
1Department of Rheumatology and Clinical Immunology, The First Hospital of Xiamen University, Xiamen 361003, China 2Laboratory of Autoimmunity, School of Biological Sciences, University of Texas at El Paso, El Paso, TX 79968, USA 3Department of Pathology and Microbiology, College of Medicine, University of Nebraska Medical Center, Omaha, NE 68198-7660, USA 4Department of Rheumatology, Peking Un...
متن کاملSystemic Autoimmune Diseases
1 Department of Rheumatology and Clinical Immunology, The First Hospital of Xiamen University, Xiamen 361003, China 2Department of Biological Sciences, University of Texas at El Paso, 500 West University Avenue, El Paso, TX 79968, USA 3Microbiology, College of Medicine University of Nebraska Medical Center, Omaha, NE 68198-7660, USA 4Department of Rheumatology, Peking Union Medical College Hosp...
متن کاملAutoimmune and Inflammatory Diseases Biomarkers
One of the major challenges facing the healthcare industry is how to personalize, or tailor healthcare products and services to individuals' unique genetic and biomarker make-ups. Biomarkers are characteristics that can be objectively measured and evaluated. They provide information about normal or patho-physiological processes to detect or define disease progression or to predict or quantify t...
متن کاملRole of neutrophils in systemic autoimmune diseases
Neutrophils have emerged as important regulators of innate and adaptive immune responses. Recent evidence indicates that neutrophils display marked abnormalities in phenotype and function in various systemic autoimmune diseases, and may play a central role in initiation and perpetuation of aberrant immune responses and organ damage in these conditions. This review discusses the putative roles t...
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ژورنال
عنوان ژورنال: Nature Reviews Rheumatology
سال: 2011
ISSN: 1759-4790,1759-4804
DOI: 10.1038/nrrheum.2011.157